Forskolin


laush

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Vist et af de eneste studier hvor oral indtagelse af forskolin viser effekt i mennesket. Det lyder faktisk helt lovende. Gad godt at se de konkrete tal på hvor stor stigning der var i "free testosterone" og hvor meget "metabolic rate" steg-

Obes Res. 2005 Aug;13(8):1335-43. Related Articles, Links

Body composition and hormonal adaptations associated with forskolin consumption in overweight and obese men.

Godard MP, Johnson BA, Richmond SR.

University of Kansas, Department of Health, Sport and Exercise Sciences, Applied Physiology Laboratory, Lawrence, KS 66045, USA. [email protected]

OBJECTIVE: This study examined the effect of forskolin on body composition, testosterone, metabolic rate, and blood pressure in overweight and obese (BMI > or = 26 kg/m(2)) men. RESEARCH METHODS AND PROCEDURE: Thirty subjects (forskolin, n = 15; placebo, n = 15) were studied in a randomized, double-blind, placebo-controlled study for 12 weeks. RESULTS: Forskolin was shown to elicit favorable changes in body composition by significantly decreasing body fat percentage (BF%) and fat mass (FM) as determined by DXA compared with the placebo group (p < or = 0.05). Additionally, forskolin administration resulted in a change in bone mass for the 12-week trial compared with the placebo group (p < or = 0.05). There was a trend toward a significant increase for lean body mass in the forskolin group compared with the placebo group (p = 0.097). Serum free testosterone levels were significantly increased in the forskolin group compared with the placebo group (p < or = 0.05). The actual change in serum total testosterone concentration was not significantly different among groups, but it increased 16.77 +/- 33.77% in the forskolin group compared with a decrease of 1.08 +/- 18.35% in the placebo group. DISCUSSION: Oral ingestion of forskolin (250 mg of 10% forskolin extract twice a day) for a 12-week period was shown to favorably alter body composition while concurrently increasing bone mass and serum free testosterone levels in overweight and obese men. The results indicate that forskolin is a possible therapeutic agent for the management and treatment of obesity.

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Ja punktslakning kan godt lade sig gøre med sådanne tiltag. Tror dog ikke at cremer med indhold af stoffer der kan penetrere huden og nå fedtcellerne er tilladt i DK uden recept?

Mht forskolin skulle effekten være en aktivering af adenyl cyclase uden en forudgående receptor aktivering som ved f.eks. beta2 agonister. Er der nogen der yderligere kan forklare hvad aktivering af adenyl cylase i fedtceller (og andre celler) gør for nedbrydningen af fedt? adenyl cyclase er så vidt jeg husker en intracellulær transmitter der igen aktiverer andre stoffer og på den måde starter en kaskade af intracellulære effekter? Men hvornår sker selve fedtnedbyrdningen?

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Binding af adrenalin (og lignende stoffer ex. amfetamin og efedrin) til beta-adrenerge receptorer aktiverer adenyl cyclase, derved øges cAMP niveauet. cAMP aktiverer bl.a. en lipase (HSL), der nedbryder fedtvæv til frie fedtsyrer der udledes til blodet. Det er fint nok, men da adrenalin etc. også binder til andre receptorer fås de kendte bivirkninger. Forskolin skulle som du siger aktivere adenyl cyclase udenom de beta-adrenerge receptorer.

Edit: Mht. cremerne, så trænger en lang række stoffer i almindelige cremer ind igennem huden, der er jo meget snak om de skadelige virkninger af parfume og parabener, så det vil nok ikke være argumentet de vil bruge imod de cremer.

Fandt en opsummering her: http://www.thinkmuscle.com/articles/jalali/forskolin.htm den er ikke helt ny, men du kan måske finde noget ekstra info der.

Edited by Dines
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